Metabolism Ketamine is metabolized via N-dealkylation to your active metabolite norketamine principally by CYP2B6 and CYP3A4 also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation of your cyclohexone ring to kind hydroxynorketamine compounds by means of CYP-dependent pathways, which are conjugated with glucuronic acid and